William M. de Souza, PhD
Connect
(859) 218 4268wmdesouza@uky.edu
Positions
- Assistant Professor
College Unit(s)
Biography and Education
Education
Postdoctoral Fellow at University of Texas Medical Branch, Galveston, TX, USA.
Ph.D. in Basic and Applied Immunology (Virology), University of S茫o Paulo, Brazil.
M.Sc. in Basic and Applied Immunology (Virology), University of S茫o Paulo, Brazil.
Research
Our lab works on understanding virus-host interactions and the transmission dynamics of arboviruses that cause human diseases. We use a transdisciplinary approach that combines virology, immunology, genomics, proteomics, metabolomics, and computational methods to advance basic and translational knowledge. Our goal is to improve public health outcomes by strengthening our ability to anticipate, prepare for, and mitigate arbovirus outbreaks and epidemics. We are also dedicated to training current and future arbovirus researchers
Selected Publications
Scachetti GC, Forato J, Claro IM, Hua X, Salgado BB, Vieira A, Simeoni CL, Barbosa ARC, Rosa IL, de Souza GF, Fernandes LCN, de Sena ACH, Oliveira SC, Singh CML, de Lima STS, de Jesus R, Costa MA, Kato RB, Rocha JF, Santos LC, Rodrigues JT, Cunha MP, Sabino EC, Faria NR, Weaver SC, Romano CM, Lalwani P, Proenca-Modena JL, de Souza WM. Re-emergence of Oropouche virus between 2023 and 2024 in Brazil: an observational epidemiological study. . 2025 Feb;25(2):166-175.
Campos AS, Franco AC, Godinho FM, Huff R, Candido DS, da Cruz Cardoso J, Hua X, Claro IM, Morais P, Franceschina C, de Lima Bermann T, Dos Santos FM, Bauermann M, Selayaran TM, Ruivo AP, Santin C, Bonella J, Rodenbusch C, Ferreira JC, Weaver SC, Gewehr VR, Wallau GL, de Souza WM, Salvato RS. Molecular Epidemiology of Western Equine Encephalitis Virus, South America, 2023-2024. . 2024 Sep;30(9):1834-1840.
de Souza WM, Weaver SC. Effects of climate change and human activities on vector-borne diseases. . 2024 Aug;22(8):476-491.
de Souza WM, Fumagalli MJ, de Lima STS, Parise PL, Carvalho DCM, Hernandez C, de Jesus R, Delafiori J, Candido DS, Carregari VC, Muraro SP, Souza GF, Sim玫es Mello LM, Claro IM, D铆az Y, Kato RB, Trentin LN, Costa CHS, Maximo ACBM, Cavalcante KF, Fiuza TS, Viana VAF, Melo MEL, Ferraz CPM, Silva DB, Duarte LMF, Barbosa PP, Amorim MR, Judice CC, Toledo-Teixeira DA, Ramundo MS, Aguilar PV, Ara煤jo ELL, Costa FTM, Cerqueira-Silva T, Khouri R, Boaventura VS, Figueiredo LTM, Fang R, Moreno B, L贸pez-Verg猫s S, Mello LP, Skaf MS, Catharino RR, Granja F, Martins-de-Souza D, Plante JA, Plante KS, Sabino EC, Diamond MS, Eugenin E, Proen莽a-M贸dena JL, Faria NR, Weaver SC. Pathophysiology of chikungunya virus infection associated with fatal outcomes. . 2024 Apr 10;32(4):606-622.e8.
Forato J, Meira CA, Claro IM, Amorim MR, de Souza GF, Muraro SP, Toledo-Teixeira DA, Dias MF, Meneses CAR, Angerami RN, Lalwani P, Weaver SC, Sabino EC, Faria NR, de Souza WM, Granja F, Proenca-Modena JL. Molecular Epidemiology of Mayaro Virus among Febrile Patients, Roraima State, Brazil, 2018-2021. . 2024 May;30(5):1013-1016. doi: 10.3201/eid3005.231406. PMID: 38666638; PMCID: PMC11060474.
de Souza WM, Gaye A, Ndiaye EH, Morgan AL, Sylla EHD, Sy FA, Diallo M, Weaver SC. Serosurvey of Chikungunya Virus in Old World Fruit Bats, Senegal, 2020-2022. . 2024 Jul;30(7):1490-1492.
de Souza WM, Ribeiro GS, de Lima STS, de Jesus R, Moreira FRR, Whittaker C, Sallum MAM, Carrington CVF, Sabino EC, Kitron U, Faria NR, Weaver SC. Chikungunya: a decade of burden in the Americas. . 2024 Jan 8;30:100673.
de Souza WM, de Lima STS, Sim玫es Mello LM, Candido DS, Buss L, Whittaker C, Claro IM, Chandradeva N, Granja F, de Jesus R, Lemos PS, Toledo-Teixeira DA, Barbosa PP, Firmino ACL, Amorim MR, Duarte LMF, Pessoa IB Jr, Forato J, Vasconcelos IL, Maximo ACBM, Ara煤jo ELL, Perdig茫o Mello L, Sabino EC, Proen莽a-M贸dena JL, Faria NR, Weaver SC. Spatiotemporal dynamics and recurrence of chikungunya virus in Brazil: an epidemiological study. . 2023 May;4(5):e319-e329.
Brizzi A, Whittaker C, Servo LMS, Hawryluk I, Prete CA Jr, de Souza WM, Aguiar RS, Araujo LJT, Bastos LS, Blenkinsop A, Buss LF, Candido D, Castro MC, Costa SF, Croda J, de Souza Santos AA, Dye C, Flaxman S, Fonseca PLC, Geddes VEV, Gutierrez B, Lemey P, Levin AS, Mellan T, Bonfim DM, Miscouridou X, Mishra S, Monod M, Moreira FRR, Nelson B, Pereira RHM, Ranzani O, Schnekenberg RP, Semenova E, Sonabend R, Souza RP, Xi X, Sabino EC, Faria NR, Bhatt S, Ratmann O. Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals. . 2022 Jul;28(7):1476-1485.
de Souza WM, Amorim MR, Sesti-Costa R, Coimbra LD, Brunetti NS, Toledo-Teixeira DA, de Souza GF, Muraro SP, Parise PL, Barbosa PP, Bispo-Dos-Santos K, Mofatto LS, Simeoni CL, Claro IM, Duarte ASS, Coletti TM, Zangirolami AB, Costa-Lima C, Gomes ABSP, Buscaratti LI, Sales FC, Costa VA, Franco LAM, Candido DS, Pybus OG, de Jesus JG, Silva CAM, Ramundo MS, Ferreira GM, Pinho MC, Souza LM, Rocha EC, Andrade PS, Crispim MAE, Maktura GC, Manuli ER, Santos MNN, Camilo CC, Angerami RN, Moretti ML, Spilki FR, Arns CW, Addas-Carvalho M, Benites BD, Vinolo MAR, Mori MAS, Gaburo N, Dye C, Marques-Souza H, Marques RE, Farias AS, Diamond MS, Faria NR, Sabino EC, Granja F, Proen莽a-M贸dena JL. Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: an immunological study. . 2021 Oct;2(10):e527-e535.
Faria NR, Mellan TA, Whittaker C, Claro IM, Candido DDS, Mishra S, Crispim MAE, Sales FCS, Hawryluk I, McCrone JT, Hulswit RJG, Franco LAM, Ramundo MS, de Jesus JG, Andrade PS, Coletti TM, Ferreira GM, Silva CAM, Manuli ER, Pereira RHM, Peixoto PS, Kraemer MUG, Gaburo N Jr, Camilo CDC, Hoeltgebaum H, de Souza WM, Rocha EC, de Souza LM, de Pinho MC, Araujo LJT, Malta FSV, de Lima AB, Silva JDP, Zauli DAG, Ferreira ACS, Schnekenberg RP, Laydon DJ, Walker PGT, Schl眉ter HM, Dos Santos ALP, Vidal MS, Del Caro VS, Filho RMF, Dos Santos HM, Aguiar RS, Proen莽a-Modena JL, Nelson B, Hay JA, Monod M, Miscouridou X, Coupland H, Sonabend R, Vollmer M, Gandy A, Prete CA Jr, Nascimento VH, Suchard MA, Bowden TA, Pond SLK, Wu CH, Ratmann O, Ferguson NM, Dye C, Loman NJ, Lemey P, Rambaut A, Fraiji NA, Carvalho MDPSS, Pybus OG, Flaxman S, Bhatt S, Sabino EC. Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil. . 2021 May 21;372(6544):815-821.
de Lima STS, de Souza WM, Cavalcante JW, da Silva Candido D, Fumagalli MJ, Carrera JP, Sim玫es Mello LM, De Carvalho Ara煤jo FM, Cavalcante Ramalho IL, de Almeida Barreto FK, de Melo Braga DN, Simi茫o AR, Miranda da Silva MJ, Alves Barbosa Oliveira RM, Lima CPS, de Sousa Lins C, Barata RR, Pereira Melo MN, Caldas de Souza MP, Franco LM, Fernandes T谩vora FR, Queiroz Lemos DR, de Alencar CHM, de Jesus R, de Souza Fonseca V, Dutra LH, de Abreu AL, Lima Ara煤jo EL, Ribas Freitas AR, Vianez J煤nior JLDSG, Pybus OG, Figueiredo LTM, Faria NR, Nunes MRT, Cavalcanti LPG, Miyajima F. Fatal Outcome of Chikungunya Virus Infection in Brazil. . 2021 Oct 5;73(7):e2436-e2443.
de Souza WM, Buss LF, Candido DDS, Carrera JP, Li S, Zarebski AE, Pereira RHM, Prete CA Jr, de Souza-Santos AA, Parag KV, Belotti MCTD, Vincenti-Gonzalez MF, Messina J, da Silva Sales FC, Andrade PDS, Nascimento VH, Ghilardi F, Abade L, Gutierrez B, Kraemer MUG, Braga CKV, Aguiar RS, Alexander N, Mayaud P, Brady OJ, Marcilio I, Gouveia N, Li G, Tami A, de Oliveira SB, Porto VBG, Ganem F, de Almeida WAF, Fantinato FFST, Mac谩rio EM, de Oliveira WK, Nogueira ML, Pybus OG, Wu CH, Croda J, Sabino EC, Faria NR. Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil. . 2020 Aug;4(8):856-865.
Candido DS, Claro IM, de Jesus JG, de Souza WM, Moreira FRR, Dellicour S, Mellan TA, du Plessis L, Pereira RHM, Sales FCS, Manuli ER, Th茅z茅 J, Almeida L, Menezes MT, Voloch CM, Fumagalli MJ, Coletti TM, da Silva CAM, Ramundo MS, Amorim MR, Hoeltgebaum HH, Mishra S, Gill MS, Carvalho LM, Buss LF, Prete CA Jr, Ashworth J, Nakaya HI, Peixoto PS, Brady OJ, Nicholls SM, Tanuri A, Rossi 脕D, Braga CKV, Gerber AL, de C Guimar茫es AP, Gaburo N Jr, Alencar CS, Ferreira ACS, Lima CX, Levi JE, Granato C, Ferreira GM, Francisco RS Jr, Granja F, Garcia MT, Moretti ML, Perroud MW Jr, Casti帽eiras TMPP, Lazari CS, Hill SC, de Souza Santos AA, Simeoni CL, Forato J, Sposito AC, Schreiber AZ, Santos MNN, de S谩 CZ, Souza RP, Resende-Moreira LC, Teixeira MM, Hubner J, Leme PAF, Moreira RG, Nogueira ML; Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) Genomic Network; Ferguson NM, Costa SF, Proenca-Modena JL, Vasconcelos ATR, Bhatt S, Lemey P, Wu CH, Rambaut A, Loman NJ, Aguiar RS, Pybus OG, Sabino EC, Faria NR. Evolution and epidemic spread of SARS-CoV-2 in Brazil. . 2020 Sep 4;369(6508):1255-1260.